Article
FGFR1 abrogates inhibitory effect of androgen receptor concurrent with induction of androgen-receptor variants in androgen receptor-negative prostate tumor epithelial cells.
The Prostate - 1 Nov 2011
Kobayashi Masashi, Huang Yanqing, Jin Chengliu, Luo Yongde, Okamoto Tetsuji, Wang Fen, McKeehan Wallace L
Abstract excerpt
BACKGROUND: Despite dramatic positive effects, there is evidence that the androgen receptor (AR) may negatively influence prostate tumor progression. Understanding the AR repressor function and how it is subverted is of particular importance in anti-androgen and AR intervention strategies. METHODS: AR, resident FGFR2IIIb, and ectopic FGFR1 were expressed by transfection in the AR-negative epithelial cell line DTE...
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