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Article

Alternative splicing of fibroblast growth factor receptors in human prostate cancer

1 Jan 2001

Abstract excerpt

BACKGROUND: Fibroblast growth factors (FGFs) are known to play an important role in the growth of normal prostatic epithelial cells and may promote proliferation of neoplastic prostatic epithelial cells via autocrine or paracrine mechanisms. The affinity of FGFs for FGF receptors 1-3 is critically dependent on an alternative splicing event involving the coding region for the carboxy terminal portion of the third...

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PMID: 11170144
DOI: 10.1002/1097-0045(20010201)46:2<163::aid-pros1020>3.0.co;2-t

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