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Article

Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease.

Human molecular genetics - 1 May 1998

Brindle N, Song Y, Rogaeva E, Premkumar S, Levesque G, Yu G, Ikeda M, Nishimura M, Paterson A, Sorbi S, Duara R, Farrer L, St George-Hyslop P

Abstract excerpt

The K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the epsilon4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE . Our...

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Source

Identifiers

PMID: 9536099
DOI: 10.1093/hmg/7.5.933

Genes

BCHE
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease.PMID 9536099Read ↗

The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations.Semantic proximity Read ↗

No association between the K variant of the butyrylcholinesterase gene and pathologically confirmed Alzheimer's disease.Semantic proximity Read ↗

The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease.Semantic proximity Read ↗

No association between butyrylcholinesterase K-variant and Alzheimer disease in Chinese.Semantic proximity Read ↗

Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease.Semantic proximity Read ↗

No association between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer's disease.Semantic proximity Read ↗

Butyrylcholinesterase K variant and Alzheimer's disease risk: a meta-analysis.Semantic proximity Read ↗

Butyrylcholinesterase K variant is genetically associated with late onset Alzheimer's disease in Northern Ireland.Semantic proximity Read ↗

Butyrycholinesterase K variant and Alzheimer's disease.Semantic proximity Read ↗

Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains.Semantic proximity Read ↗

Butyrylcholinesterase K variant on chromosome 3 q is associated with Type II diabetes in white Caucasian subjects.Semantic proximity Read ↗

Analysis of association between butyrylcholinesterase K variant and apolipoprotein E genotypes in Alzheimer's disease.Semantic proximity Read ↗

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