Article
Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease.
Human molecular genetics - 1 May 1998
Brindle N, Song Y, Rogaeva E, Premkumar S, Levesque G, Yu G, Ikeda M, Nishimura M, Paterson A, Sorbi S, Duara R, Farrer L, St George-Hyslop P
Abstract excerpt
The K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the epsilon4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial...
Topics
- Aged
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Butyrylcholinesterase
- Chromosomes, Human, Pair 3
- Female
- Gene Frequency
- Genetic Markers
- Humans
- Male
- Middle Aged