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Article

Loss-of-function mutations in the mtr efflux system of Neisseria gonorrhoeae

1 Mar 1998

Abstract excerpt

Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents (HAs) has been ascribed to the mtr (multiple transferable resistance) operon. This operon is composed of the mtrR gene, which encodes a transcriptional repressor (MtrR), and a three-gene complex (mtrCDE), which encodes cell envelope proteins (MtrC-MtrD-MtrE) that form an energy-dependent efflux pump. HA-hypersusceptible strains are often...

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PMID: 9534233
DOI: 10.1099/00221287-144-3-621

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Loss-of-function mutations in the mtr efflux system of Neisseria gonorrhoeaePMID 9534233Read ↗

Identification of a cell envelope protein (MtrF) involved in hydrophobic antimicrobial resistance in Neisseria gonorrhoeae.Semantic proximity Read ↗

Transcriptional control of the mtr efflux system of Neisseria gonorrhoeae.Semantic proximity Read ↗

Involvement of the gonococcal MtrE protein in the resistance of Neisseria gonorrhoeae to toxic hydrophobic agents.Semantic proximity Read ↗

Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system.Semantic proximity Read ↗

Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness.Semantic proximity Read ↗

Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like mtr Efflux Pump LocusSemantic proximity Read ↗

The MtrR repressor binds the DNA sequence between the mtrR and mtrC genes of Neisseria gonorrhoeae.Semantic proximity Read ↗

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Mechanistic basis for decreased antimicrobial susceptibility in a clinical isolate of <i>Neisseria gonorrhoeae</i> possessing a mosaic-like <i>mtr</i> efflux pump locusSemantic proximity Read ↗

Missense mutations that alter the DNA-binding domain of the MtrR protein occur frequently in rectal isolates of Neisseria gonorrhoeae that are resistant to faecal lipids.Semantic proximity Read ↗

Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.Semantic proximity Read ↗

Self-Inhibitory Peptides Targeting the Neisseria gonorrhoeae MtrCDE Efflux Pump Increase Antibiotic SusceptibilitySemantic proximity Read ↗

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