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Article

Involvement of the gonococcal MtrE protein in the resistance of Neisseria gonorrhoeae to toxic hydrophobic agents.

Microbiology (Reading, England) - 1 Jul 1997

Delahay R M, Robertson B D, Balthazar J T, Shafer W M, Ison C A

Abstract excerpt

Low-level resistance of Neisseria gonorrhoeae to toxic hydrophobic agents (HAs), including some antibiotics, is chromosomally mediated via the multiple transferable resistance (mtr) efflux system. The gene encoding the 48:3 kDa outer-membrane protein MtrE, which is associated with the mtr phenoty...

Topics

Amino Acid Sequence
Amino Acid Transport Systems, Neutral
Anti-Bacterial Agents
Bacterial Outer Membrane Proteins
Cloning, Molecular
Drug Resistance, Microbial
Membrane Proteins
Membrane Transport Proteins
Molecular Sequence Data
Mutation
Neisseria gonorrhoeae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis

Source

Identifiers

PMID: 9245802
DOI: 10.1099/00221287-143-7-2127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9245802-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Involvement of the gonococcal MtrE protein in the resistance of Neisseria gonorrhoeae to toxic hydrophobic agents.PMID 9245802Read ↗

Identification of a cell envelope protein (MtrF) involved in hydrophobic antimicrobial resistance in Neisseria gonorrhoeae.Semantic proximity Read ↗

Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system.Semantic proximity Read ↗

Transcriptional control of the mtr efflux system of Neisseria gonorrhoeae.Semantic proximity Read ↗

The MtrR repressor binds the DNA sequence between the mtrR and mtrC genes of Neisseria gonorrhoeae.Semantic proximity Read ↗

Loss-of-function mutations in the mtr efflux system of Neisseria gonorrhoeaeSemantic proximity Read ↗

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Missense mutations that alter the DNA-binding domain of the MtrR protein occur frequently in rectal isolates of Neisseria gonorrhoeae that are resistant to faecal lipids.Semantic proximity Read ↗

Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like mtr Efflux Pump LocusSemantic proximity Read ↗

Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness.Semantic proximity Read ↗

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Structure and Function of Neisseria gonorrhoeae MtrF Illuminates a Class of Antimetabolite Efflux PumpsSemantic proximity Read ↗

Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations.Semantic proximity Read ↗

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