Article
Missense mutations that alter the DNA-binding domain of the MtrR protein occur frequently in rectal isolates of Neisseria gonorrhoeae that are resistant to faecal lipids.
Microbiology (Reading, England) - 1 Apr 1995
Shafer W M, Balthazar J T, Hagman K E, Morse S A
Abstract excerpt
Resistance of Neisseria gonorrhoeae to structurally diverse hydrophobic agents (HAs) has been associated with missense or deletion mutations in the mtrR (multiple transferable resistance Regulator) gene of laboratory-derived strains but their prevalence in clinical isolates was heretofore unknown...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- DNA Primers
- DNA, Bacterial
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Feces
- Ferredoxin-NADP Reductase
- Genes, Bacterial
- Humans
- Lipids
- Male
- Molecular Sequence Data
- Mutation
- Neisseria gonorrhoeae
- Promoter Regions, Genetic
- Rectum