Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.

doi:10.1128/JB.184.20.5619-5624.2002

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Article

Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.

Journal of bacteriology - 1 Oct 2002

Veal Wendy L, Nicholas Robert A, Shafer William M

Abstract excerpt

The importance of the mtrCDE-encoded efflux pump in conferring chromosomally mediated penicillin resistance on certain strains of Neisseria gonorrhoeae was determined by using genetic derivatives of penicillin-sensitive strain FA19 bearing defined mutations (mtrR, penA, and penB) donated by a clinical isolate (FA6140) expressing high-level resistance to penicillin and antimicrobial hydrophobic agents (HAs). When...

Topics

Anti-Bacterial Agents
Bacterial Outer Membrane Proteins
Bacterial Proteins
Carrier Proteins
Chromosomes, Bacterial
Drug Resistance, Multiple, Bacterial
Ferredoxin-NADP Reductase
Gene Expression Regulation, Bacterial
Humans
Lipoproteins
Membrane Proteins
Membrane Transport Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbial Sensitivity Tests

Mutation

Neisseria gonorrhoeae

Octoxynol

Penicillin Resistance

Penicillins

Source

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Identifiers

PMID: 12270819
DOI: 10.1128/JB.184.20.5619-5624.2002
PMCID: PMC139619

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