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Article

Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1 in Mexican patients: a relationship between HLA and gender is suggested.

BMC medical genetics - 15 Aug 2008

Alaez Carmen, Lin Ling, Flores-A Hilario, Vazquez Miriam, Munguia Andrea, Mignot Emmanuel, Haro Reyes, Baker Harry, Gorodezky Clara

Abstract excerpt

BACKGROUND: Narcolepsy-cataplexy is characterized by excessive daytime sleepiness with recurrent episodes of irresistible sleep, cataplexy, hallucinations and sleep paralysis. Its aetiology is unknown, but it is positively associated with the human leukocyte antigens (HLA) in all studied populations. The purpose of the present study was to investigate the association of HLA class II DRB1/DQB1 alleles with...

Topics

Alleles
Case-Control Studies
Cataplexy
Chi-Square Distribution
Female
Gene Frequency
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DR Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DRB1 Chains

Histocompatibility Testing

Humans

Male

Membrane Glycoproteins

Mexico

Narcolepsy

Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 18706091
DOI: 10.1186/1471-2350-9-79
PMCID: PMC2533302

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Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1 in Mexican patients: a relationship between HLA and gender is suggested.PMID 18706091Read ↗

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