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Article

Wilms' Tumor Gene (WT1) Competes With Differentiation-Inducing Signal in Hematopoietic Progenitor Cells

15 Apr 1998

Abstract excerpt

The WT1 gene is a tumor-suppressor gene that was isolated as a gene responsible for Wilms' tumor, a childhood kidney neoplasm. We have previously reported that the WT1 gene is strongly expressed in leukemia cells with an increase in its expression levels at relapse and an inverse correlation between its expression levels and prognosis, thus making it a novel tumor marker for leukemic blast cells. Furthermore, WT1...

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Identifiers

PMID: 9531608
DOI: 10.1182/blood.v91.8.2969.2969_2969_2976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Wilms' Tumor Gene (WT1) Competes With Differentiation-Inducing Signal in Hematopoietic Progenitor CellsPMID 9531608Read ↗

Role of the WT1 tumor suppressor in murine hematopoiesisSemantic proximity Read ↗

Constitutive expression of the Wilms’ tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF)Semantic proximity Read ↗

Role of the Wilms’ tumor 1 gene in the aberrant biological behavior of leukemic cells and the related mechanismsSemantic proximity Read ↗

WT1 overexpression in acute myeloid leukemia and myelodysplastic syndromes.Semantic proximity Read ↗

AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1Semantic proximity Read ↗

Wilms' tumor gene 1 protein represses the expression of the tumor suppressor interferon regulatory factor 8 in human hematopoietic progenitors and in leukemic cells.Semantic proximity Read ↗

The Wilms tumor suppressor WT1 directs stage‐specific quiescence and differentiation of human hematopoietic progenitor cellsSemantic proximity Read ↗

The Wilms' Tumor 1 Tumor Suppressor Gene Represses Transcription of the Human Telomerase Reverse Transcriptase GeneSemantic proximity Read ↗

Analysis of WT1 target gene expression in stably transfected cell lines.Semantic proximity Read ↗

A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells.Semantic proximity Read ↗

Mutations of the WT1 gene in childhood nonlymphoid hematological malignancies.Semantic proximity Read ↗

A Pathologic Link between Wilms Tumor Suppressor Gene, WT1, and IFI16Semantic proximity Read ↗

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