Article
WT1 overexpression in acute myeloid leukemia and myelodysplastic syndromes.
Methods in molecular medicine - 1 Jan 2006
Cilloni Daniela, Gottardi Enrico, Saglio Giuseppe
Abstract excerpt
The Wilms tumor gene was identified as a tumor suppressor gene responsible for a particular type of kidney tumor. Several years ago, it was demonstrated that it is also overexpressed in acute and chronic leukemias. Although the exact role of this gene in the hematopoietic system is still quite completely obscure, it represents a reliable marker for the detection of the presence of leukemic cells. WT1 quantitative...
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