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Article

Role of the WT1 tumor suppressor in murine hematopoiesis

17 Mar 2003

Abstract excerpt

The WT1 tumor-suppressor gene is expressed by many forms of acute myeloid leukemia. Inhibition of this expression can lead to the differentiation and reduced growth of leukemia cells and cell lines, suggesting that WT1 participates in regulating the proliferation of leukemic cells. However, the role of WT1 in normal hematopoiesis is not well understood. To investigate this question, we have used murine cells in...

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Identifiers

PMID: 12468434
DOI: 10.1182/blood-2002-06-1656

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