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Article

Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning.

Journal of cell science - 15 Jan 2010

Lam Connie, Vergnolle Maïlys A S, Thorpe Lisa, Woodman Philip G, Allan Victoria J

Abstract excerpt

LIS1, NDE1 and NDEL1 modulate cytoplasmic dynein function in several cellular contexts. However, evidence that they regulate dynein-dependent organelle positioning is limited. Here, we show that depletion of NDE1 or NDEL1 alone profoundly affected the organisation of the Golgi complex but did not...

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Share to 1-Alkyl-2-acetylglycerophosphocholine Esterase
Share to cdc42 GTP-Binding Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20048338
DOI: 10.1242/jcs.059337

Genes

NDE1
NDEL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20048338-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning.PMID 20048338Read ↗

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[Molecular mechanism of lissencephaly--how LIS1 and NDEL1 regulate cytoplasmic dynein?].Semantic proximity Read ↗

NudEL targets dynein to microtubule ends through LIS1.Semantic proximity Read ↗

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NDE1 Localizes to the Subdistal Appendages to Maintain Centrosome Integrity and Microtubule OrganizationSemantic proximity Read ↗

Mechanism of positioning the cell nucleus in vertebrate photoreceptors.Semantic proximity Read ↗

PACS1 syndrome mutation disrupts dynein-mediated cargo transport via HDAC6 and BICD2.Semantic proximity Read ↗

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Pac1/LIS1 promotes an uninhibited conformation of dynein that coordinates its localization and activitySemantic proximity Read ↗

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