The fission yeast SPB component Cut12 links bipolar spindle formation to mitotic control.

doi:10.1101/gad.12.7.927

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Article

The fission yeast SPB component Cut12 links bipolar spindle formation to mitotic control.

Genes & development - 1 Apr 1998

Bridge A J, Morphew M, Bartlett R, Hagan I M

Abstract excerpt

During fission yeast mitosis, the duplicated spindle pole bodies (SPBs) nucleate microtubule arrays that interdigitate to form the mitotic spindle. cut12.1 mutants form a monopolar mitotic spindle, chromosome segregation fails, and the mutant undergoes a lethal cytokinesis. The cut12(+) gene enco...

Topics

Amino Acid Sequence
Base Sequence
Fluorescent Antibody Technique
Gene Deletion
Genes, Fungal
Microtubule-Associated Proteins
Mitosis
Molecular Sequence Data
Mutation
Phosphoproteins
Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Spindle Apparatus

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