Article
Neutrophil granulocyte-committed cells can be driven to acquire dendritic cell characteristics.
The Journal of experimental medicine - 6 Apr 1998
Oehler L, Majdic O, Pickl W F, Stöckl J, Riedl E, Drach J, Rappersberger K, Geissler K, Knapp W
Abstract excerpt
Polymorphonuclear granulocytes (PMNs) are thought to fulfill their role in host defense primarily via phagocytosis and release of cytotoxic compounds and to be inefficient in antigen presentation and stimulation of specific T cells. Dendritic cells (DCs), in contrast, are potent antigen-presenting cells with the unique capacity to initiate primary immune responses. We demonstrate here that highly purified...
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