Article
The significance of the 3'-nontranslated region and E2 amino acid mutations in the virulence of Semliki Forest virus in mice.
Virology - 30 Mar 1998
Santagati M G, Määttä J A, Röyttä M, Salmi A A, Hinkkanen A E
Abstract excerpt
We have recently shown that the 3'-nontranslated region (3'-NTR) of the avirulent Semliki Forest virus A7(74) [SFVA7(74)] contains a unique sequence of 101 nucleotides and five repetitive nucleotide units whereas the 3'-NTR of the neurovirulent SFV4 has only two repeats. A chimeric virus was constructed by replacing the entire 3'-NTR of the SFV4 clone with the A7(74) 3'-NTR. The hybrid replicated efficiently in...
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