Article
Two mutations in the envelope glycoprotein E2 of Semliki Forest virus affecting the maturation and entry patterns of the virus alter pathogenicity for mice.
Virology - 1 Dec 1991
Glasgow G M, Sheahan B J, Atkins G J, Wahlberg J M, Salminen A, Liljeström P
Abstract excerpt
The prototype strain of Semliki Forest virus (SFV) of known sequence and virus produced by the cDNA clone derived from it were lethal following intranasal (i.n.) infection of 40-day-old and intraperitoneal (i.p.) infection of pregnant BALB/c mice; this lethality was related to neuronal necrosis i...
Topics
- Animals
- Brain
- Cells, Cultured
- Central Nervous System Diseases
- Cloning, Molecular
- Cricetinae
- Female
- Fetal Diseases
- Kinetics
- Mice
- Mice, Inbred BALB C
- Mutation
- Precipitin Tests
- Pregnancy
- Pregnancy Complications, Infectious
- Semliki forest virus
- Togaviridae Infections
- Viral Envelope Proteins