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Article

Amino acid mutations in the replicase protein nsP3 of Semliki Forest virus cumulatively affect neurovirulence.

The Journal of general virology - 1 Jun 2003

Tuittila Minna, Hinkkanen Ari E

Abstract excerpt

It has been shown previously that an avirulent Semliki Forest virus (SFV) clone, rA774, engineered to carry the nsP3 gene of the virulent clone SFV4 becomes highly neurovirulent and is lethal for adult BALB/c mice. rA774, like several other alphaviruses, has an opal termination codon close to the 5' end of nsP3 (aa 469), while SFV4 has an arginine residue at this position. Mutation of the opal codon to an...

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PMID: 12771422
DOI: 10.1099/vir.0.18936-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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