Article
Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes.
The Journal of clinical investigation - 1 Jan 1994
Sorensen P H, Chen C S, Smith F O, Arthur D C, Domer P H, Bernstein I D, Korsmeyer S J, Hammond G D, Kersey J H
Abstract excerpt
Cytogenetic studies have previously identified abnormalities of chromosome band 11q23 in many cases of infant acute leukemia. Recent studies by ourselves and others have demonstrated breakpoint clustering in acute leukemias bearing translocations involving 11q23, and a Drosophila trithorax gene homologue (called MLL, HRX, or ALL-1) has been shown to span the 11q23 breakpoints of these translocations. To determine...
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