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Article

A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A.

Development (Cambridge, England) - 1 May 1998

Chen Y, Riese M J, Killinger M A, Hoffmann F M

Abstract excerpt

decapentaplegic (dpp) is a Transforming Growth Factor beta (TGF-beta)-related growth factor that controls multiple developmental processes in Drosophila. To identify components involved in dpp signaling, we carried out a genetic screen for dominant enhancer mutations of a hypomorphic allele of thick veins (tkv), a type I receptor for dpp. We recovered new alleles of tkv, punt, Mothers against dpp (Mad) and Medea...

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Identifiers

PMID: 9521913
DOI: 10.1242/dev.125.9.1759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A.PMID 9521913Read ↗

Genetic analysis of punt, a type II Dpp receptor that functions throughout the Drosophila melanogaster life cycle.Semantic proximity Read ↗

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.Semantic proximity Read ↗

Identification of chromosomal regions involved in decapentaplegic function in Drosophila.Semantic proximity Read ↗

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.Semantic proximity Read ↗

Drosophila 60A gene, another transforming growth factor beta family member, is closely related to human bone morphogenetic proteins.Semantic proximity Read ↗

brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes.Semantic proximity Read ↗

Molecular organization of the decapentaplegic gene in Drosophila melanogaster.Semantic proximity Read ↗

Localized enhancement and repression of the activity of the TGF-beta family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo.Semantic proximity Read ↗

Analysis of the shortvein cis-regulatory region of the decapentaplegic gene of Drosophila melanogaster.Semantic proximity Read ↗

TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing.Semantic proximity Read ↗

An absolute requirement for both the type II and type I receptors, punt and thick veins, for dpp signaling in vivo.Semantic proximity Read ↗

Molecular lesions associated with alleles of decapentaplegic identify residues necessary for TGF-beta/BMP cell signaling in Drosophila melanogaster.Semantic proximity Read ↗

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