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Article

Structural basis for specificity of retroviral proteases.

Biochemistry - 31 Mar 1998

Wu J, Adomat J M, Ridky T W, Louis J M, Leis J, Harrison R W, Weber I T

Abstract excerpt

The Rous sarcoma virus (RSV) protease S9 variant has been engineered to exhibit high affinity for HIV-1 protease substrates and inhibitors in order to verify the residues deduced to be critical for the specificity differences. The variant has 9 substitutions (S38T, I42D, I44V, M73V, A100L, V104T,...

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Identifiers

PMID: 9521772
DOI: 10.1021/bi972183g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9521772-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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