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Article

Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease.

Protein science : a publication of the Protein Society - 1 Jul 2012

Alvizo Oscar, Mittal Seema, Mayo Stephen L, Schiffer Celia A

Abstract excerpt

HIV-1 protease recognizes and cleaves more than 12 different substrates leading to viral maturation. While these substrates share no conserved motif, they are specifically selected for and cleaved by protease during viral life cycle. Drug resistant mutations evolve within the protease that compromise inhibitor binding but allow the continued recognition of all these substrates. While the substrate envelope...

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Identifiers

PMID: 22549928
DOI: 10.1002/pro.2086
PMCID: PMC3403440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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