Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Substrate requirements of a human rhinoviral 2A proteinase.

Virology - 1 Mar 1991

Skern T, Sommergruber W, Auer H, Volkmann P, Zorn M, Liebig H D, Fessl F, Blaas D, Kuechler E

Abstract excerpt

The genetic information contained within the RNA genome of picornaviruses is expressed as a single large open reading frame; processing of the primary translation product begins while translation is still in progress. In rhinoviruses and enteroviruses, two picornavirus genera, the virally encoded proteinase 2A begins the processing cascade, cleaving between the C-terminus of VP1 and its own N-terminus. The...

Topics

Amino Acid Sequence
Cysteine Endopeptidases
Enterovirus
Genetic Variation
Humans
Molecular Sequence Data
Plasmids
Poliovirus
Recombinant Fusion Proteins
Rhinovirus
Sequence Homology, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Substrate Specificity

Viral Proteins

Source

Identifiers

PMID: 1847268
DOI: 10.1016/0042-6822(91)90468-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1847268-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Substrate requirements of a human rhinoviral 2A proteinase.PMID 1847268Read ↗

Defining residues involved in human rhinovirus 2A proteinase substrate recognition.Semantic proximity Read ↗

The C-terminal residues of poliovirus proteinase 2A(pro) are critical for viral RNA replication but not for cis- or trans-proteolytic cleavage.Semantic proximity Read ↗

Defining substrate selection by rhinoviral 2A proteinase through its crystal structure with the inhibitor zVAM.fmk.Semantic proximity Read ↗

Interaction of 2A proteinase of human rhinovirus genetic group A with eIF4E is required for eIF4G cleavage during infection.Semantic proximity Read ↗

Mutational analyses support a model for the HRV2 2A proteinase.Semantic proximity Read ↗

Human rhinovirus 2 2Apro recognition of eukaryotic initiation factor 4GI. Involvement of an exosite.Semantic proximity Read ↗

The 2A proteins of three diverse picornaviruses are related to each other and to the H-rev107 family of proteins involved in the control of cell proliferationSemantic proximity Read ↗

Identification of a short, highly conserved, motif required for picornavirus capsid precursor processing at distal sitesSemantic proximity Read ↗

Rhinovirus 2A is the predominant protease responsible for instigating the early block to gene expression encountered in infected cellsSemantic proximity Read ↗

Structure of Senecavirus A 3C Protease Revealed the Cleavage Pattern of 3C Protease in PicornavirusesSemantic proximity Read ↗

Picornavirus Modification of a Host mRNA Decay ProteinSemantic proximity Read ↗

Further Characterization of the Coronavirus Infectious Bronchitis Virus 3C-like Proteinase and Determination of a New Cleavage SiteSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.