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Article

Tbx1 and Foxi3 genetically interact in the pharyngeal pouch endoderm in a mouse model for 22q11.2 deletion syndrome

14 Aug 2019

Abstract excerpt

We investigated whether Tbx1, the gene for 22q11.2 deletion syndrome (22q11.2DS) and Foxi3, both required for segmentation of the pharyngeal apparatus (PA) to individual arches, genetically interact. We found that all Tbx1+/-;Foxi3+/- double heterozygous mouse embryos had thymus and parathyroid gland defects, similar to those in 22q11.2DS patients. We then examined Tbx1 and Foxi3 heterozygous, null as well as...

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PMID: 31412026
DOI: 10.1371/journal.pgen.1008301

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Tbx1 and Foxi3 genetically interact in the pharyngeal pouch endoderm in a mouse model for 22q11.2 deletion syndromePMID 31412026Read ↗

<i>Tbx1</i> and <i>Foxi3</i> genetically interact in the third pharyngeal pouch endoderm required for thymus and parathyroid developmentSemantic proximity Read ↗

Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations.Semantic proximity Read ↗

Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis.Semantic proximity Read ↗

Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice.Semantic proximity Read ↗

Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs.Semantic proximity Read ↗

Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy.Semantic proximity Read ↗

<i>Tbx1</i>expression in pharyngeal epithelia is necessary for pharyngeal arch artery developmentSemantic proximity Read ↗

Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways.Semantic proximity Read ↗

Zebrafish Pax1a and Pax1b are required for pharyngeal pouch morphogenesis and ceratobranchial cartilage development.Semantic proximity Read ↗

Single cell transcriptomics uncovers a non-autonomous <i>Tbx1</i> -dependent genetic program controlling cardiac neural crest cell deployment and progressionSemantic proximity Read ↗

Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.Semantic proximity Read ↗

Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients.Semantic proximity Read ↗

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