Article
Use of signature-tagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization.
Molecular microbiology - 1 Feb 1998
Chiang S L, Mekalanos J J
Abstract excerpt
The pathogenesis of cholera begins with colonization of the host intestine by Vibrio cholerae. The toxin co-regulated pilus (TCP), a fimbrial structure produced by V. cholerae, is absolutely required for colonization (i.e. the persistence, survival and growth of V. cholerae in the upper intestina...
Topics
- Amino Acid Sequence
- Animals
- Cholera
- DNA Transposable Elements
- Fimbriae, Bacterial
- Genes, Bacterial
- Mice
- Mice, Inbred ICR
- Mice, Inbred Strains
- Molecular Sequence Data
- Mutagenesis
- Mutation