Article
Use of signature-tagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization.
Molecular microbiology - 1 Feb 1998
Chiang S L, Mekalanos J J
Abstract excerpt
The pathogenesis of cholera begins with colonization of the host intestine by Vibrio cholerae. The toxin co-regulated pilus (TCP), a fimbrial structure produced by V. cholerae, is absolutely required for colonization (i.e. the persistence, survival and growth of V. cholerae in the upper intestinal milieu), but many other aspects of the colonization process are not well understood. In this study, we use...
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