Article
T cell responses to recombinant isoforms, synthetic peptides and a mutant variant of Lep d 2, a major allergen from the dust mite Lepidoglyphus destructor.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Dec 2001
Eriksson T L, Gafvelin G, Elfman L H, Johansson C, Van Hage-Hamsten M, Olsson S
Abstract excerpt
BACKGROUND: The dust mite Lepidoglyphus destructor is an important cause of allergic reactions to dust, especially in farming environments. Two isoforms, recombinant (r)Lep d 2.01 and rLep d 2.02, of the major allergen Lep d 2, have previously been expressed as recombinant proteins. These isoforms differ 10.4% at the amino acid level. Furthermore, a mutant form of Lep d 2.01 (rLep d 2.6Cys) with a highly reduced...
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