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Differential Dynamics and Roles of FKBP51 Isoforms and Their Implications for Targeted Therapies

16 Nov 2024

Abstract excerpt

The expression of FKBP5, and its resulting protein FKBP51, is strongly induced by glucocorticoids. Numerous studies have explored their involvement in a plethora of cellular processes and diseases. There is, however, a lack of knowledge on the role of the different RNA splicing variants and the two protein isoforms, one missing functional C-terminal motifs. In this study, we use in vitro models (HeLa and Jurkat...

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PMID: 39596380
DOI: 10.3390/ijms252212318

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