Article
An Engineered Allele of afsQ1 Facilitates the Discovery and Investigation of Cryptic Natural Products.
ACS chemical biology - 17 Mar 2017
Daniel-Ivad Martin, Hameed Nabeela, Tan Stephanie, Dhanjal Rachna, Socko Daniel, Pak Patricia, Gverzdys Tomas, Elliot Marie A, Nodwell Justin R
Abstract excerpt
New approaches to antimicrobial discovery are needed to address the growing threat of antibiotic resistance. The Streptomyces genus, a proven source of antibiotics, is recognized as having a large reservoir of untapped secondary metabolic genes, many of which are likely to produce uncharacterized compounds. However, most of these compounds are currently inaccessible, as they are not expressed under standard...
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