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Article

Proliferation and the monoclonal origins of atherosclerotic lesions.

Annual review of medicine - 1 Jan 1998

Schwartz S M, Murry C E

Abstract excerpt

Benditt's observation of the monoclonal origin of the atherosclerotic lesion has been controversial because it appeared to conflict with conventional wisdom. A new method based on a polymerase chain reaction amplification of the DNA of an X-inactivated gene from microdissected tissue confirms that Benditt was correct. However, this monoclonal expansion can also be found in nonatherosclerotic intima and media....

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Identifiers

PMID: 9509274
DOI: 10.1146/annurev.med.49.1.437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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