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Rapid accumulation of intracellular 2-keto-3-deoxy-6-phosphogluconate in an Entner-Doudoroff aldolase mutant results in bacteriostasis.

FEMS microbiology letters - 15 Feb 1998

Fuhrman L K, Wanken A, Nickerson K W, Conway T

Abstract excerpt

The accumulation of 2-keto-3-deoxy-6-phosphogluconate, the key intermediate of the Entner-Doudoroff pathway, has long been thought to inhibit growth of bacteria, but careful measurements of 2-keto-3-deoxy-6-phosphogluconate accumulation by growing cells and the correlation of intracellular 2-keto-3-deoxy-6-phosphogluconate levels to growth inhibition had not been made. A system designed for this purpose was...

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PMID: 9503620
DOI: 10.1111/j.1574-6968.1998.tb12870.x

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