Article
Depletion of glycolytic intermediates plays a key role in glucose-phosphate stress in Escherichia coli.
Journal of bacteriology - 1 Nov 2013
Richards Gregory R, Patel Maulik V, Lloyd Chelsea R, Vanderpool Carin K
Abstract excerpt
In bacteria like Escherichia coli, the accumulation of glucose-6-phosphate (G6P) or its analogs such as α-methyl glucoside-6-phosphate (αMG6P) results in stress that appears in the form of growth inhibition. The small RNA SgrS is an essential part of the response that helps E. coli combat glucose-phosphate stress; the growth of sgrS mutants during stress caused by αMG is significantly impaired. The cause of this...
Topics
- Biological Transport
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression Regulation, Bacterial
- Glucose-6-Phosphate
- Glycolysis
- Methylglucosides
- Mutation