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Article

Residue N84 of yeast cystathionine beta-synthase is a determinant of reaction specificity.

Biochimica et biophysica acta - 1 Jul 2010

Lodha Pratik H, Hopwood Emily M S, Manders Adrienne L, Aitken Susan M

Abstract excerpt

Cystathionine beta-synthase (CBS) catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of L-serine and L-homocysteine to form L-cystathionine in the first step of the reverse transsulfuration pathway. Residue N84 of yeast CBS (yCBS), predicted to form a hydrogen bond with the hydroxyl moiety of the PLP cofactor, was mutated to alanine, aspartate and histidine. The truncated form of yCBS (ytCBS,...

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Source

Identifiers

PMID: 20176145
DOI: 10.1016/j.bbapap.2010.02.010

Genes

CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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