Inhibition of HIV-1 replication by a monoclonal antibody directed toward the complementarity determining region 3-like domain of CD4 in CD45 expressing and CD45-deficient cells.

Abstract excerpt

Monoclonal antibodies directed toward the complementarity determining region (CDR)3-like loop of the aminoterminal domain of CD4 have been shown to inhibit the replication of human immunodeficiency virus (HIV) in CD4 positive T cells. The mechanism of action of these antibodies is not yet elucida...

Topics

• Antibodies, Monoclonal
• CD4 Antigens
• CD4-Positive T-Lymphocytes
• Flow Cytometry
• Genetic Variation
• HIV-1
• Humans
• Jurkat Cells
• Leukocyte Common Antigens
• Time Factors
• Virus Replication