Article
In vitro selection of HIV-1 resistant to an anti-CD4 monoclonal antibody that inhibits virus transcription.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 Jan 1998
Coudronnière N, David C, Hirn M, Devaux C
Abstract excerpt
Phase I studies using monoclonal antibodies (mAbs) that bind to the Ig-CDR3-like loop in domain 1 of CD4 (e.g., 13B8-2 mAb) have already been documented for HIV-1-infected patients. In vitro, such mAbs do not inhibit virus to cell fusion but are able to inhibit virus envelope-mediated syncytia fo...
Topics
- Anti-HIV Agents
- Base Sequence
- CD4 Antigens
- Cell Fusion
- Cloning, Molecular
- Drug Resistance, Microbial
- Genes, tat
- HIV Envelope Protein gp120
- HIV Long Terminal Repeat
- HIV-1
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Neutralization Tests
- Selection, Genetic
- Sequence Analysis, DNA