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Article

Multiple sites required for expression in 5'-flanking region of the hMLH1 gene.

Gene - 13 Mar 2003

Arita Michitsune, Zhong Xiaoling, Min Zhenghua, Hemmi Hiromichi, Shimatake Hiroyuki

Abstract excerpt

Expression of the hMLH1 gene, one of the DNA mismatch repair genes, is frequently repressed in various cancers such as colorectal, ovarian, gastric, and endometrial origins with a microsatellite instable phenotype. In this study, we investigated details of the relationship between the transcriptional activity and the protein-binding sites in the 5'-flanking region of the hMLH1 gene. Luciferase reporter gene...

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Source

Identifiers

PMID: 12657467
DOI: 10.1016/s0378-1119(03)00385-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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