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Article

Structure of the human MLH1 locus and analysis of a large hereditary nonpolyposis colorectal carcinoma kindred for mlh1 mutations.

Cancer research - 15 Jan 1995

Kolodner R D, Hall N R, Lipford J, Kane M F, Morrison P T, Finan P J, Burn J, Chapman P, Earabino C, Merchant E

Abstract excerpt

Hereditary nonpolyposis colorectal carcinoma is a major cancer susceptibility syndrome known to be caused by inheritance of mutations in at least four genes such as hMSH2, hMLH1, hPMS1, and hPMS2 which encode components of a DNA mismatch repair system. The hMLH1 genomic locus on chromosome 3p has been cloned and shown to cover approximately 58 kilobases of genomic DNA and contain 19 exons. The sequence of all of...

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PMID: 7812952

Genes

MLH1

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Structure of the human MLH1 locus and analysis of a large hereditary nonpolyposis colorectal carcinoma kindred for mlh1 mutations.PMID 7812952Read ↗

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