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Article

Prion protein (PrPc) promotes beta-amyloid plaque formation.

Neurobiology of aging - 1 Jan 2000

Schwarze-Eicker Katja, Keyvani Kathy, Görtz Nicole, Westaway David, Sachser Norbert, Paulus Werner

Abstract excerpt

Prion protein (PrP) has been localized to amyloid-beta (Abeta) senile plaques in aging and Alzheimer disease, but it is unknown whether PrP is directly involved in plaque formation or represents a reaction to amyloid deposition. To evaluate possible functional effects of PrP in Abeta plaque forma...

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Source

Identifiers

PMID: 15917101
DOI: 10.1016/j.neurobiolaging.2004.10.004

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15917101-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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