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Article

Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations.

Nature reviews. Cancer - 1 Dec 2007

Fackenthal James D, Olopade Olufunmilayo I

Abstract excerpt

Germline mutations in the BRCA1 or BRCA2 tumour-suppressor genes are strong predictors of breast and/or ovarian cancer development. The contribution of these mutations to breast cancer risk within any specific population is a function of both their prevalence and their penetrance. Mutation prevalence varies among ethnic groups and may be influenced by founder mutations. Penetrance can be influenced by...

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Source

Identifiers

PMID: 18034184
DOI: 10.1038/nrc2054

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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