Article
The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens.
Immunity - 1 Feb 1998
Van Parijs L, Peterson D A, Abbas A K
Abstract excerpt
We have examined the role of Fas and Bcl-2 in T cell survival and responses to antigen in vivo using T cells that express a transgenic antigen receptor specific for hen egg lysozyme (HEL) and that either lack functional Fas or Fas ligand (FasL) or overexpress Bcl-2 as a transgene. HEL-specific, B...
Topics
- Adoptive Transfer
- Animals
- Apoptosis
- Autoantibodies
- Enzyme-Linked Immunosorbent Assay
- Fas Ligand Protein
- Homeostasis
- Immune Tolerance
- Ligands
- Lymphocyte Activation
- Membrane Glycoproteins
- Mice
- Mice, Mutant Strains
- Mice, Transgenic
- Muramidase
- Peptide Fragments
- Phenotype
- Polymerase Chain Reaction