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Article

Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens.

Frontiers in immunology - 1 Jan 2021

Flores-Mendoza Giovanna, Rodríguez-Rodríguez Noé, Rubio Rosa M, Madera-Salcedo Iris K, Rosetti Florencia, Crispín José C

Abstract excerpt

Activation of self-reactive CD8+ T cells induces a peripheral tolerance mechanism that involves loss of CD8 expression. Because genetic deficiency of Fas and Fasl causes the accumulation of double-negative (DN; CD3+ TCR-αβ+ CD4- CD8-) T cells that have been proposed to derive from CD8+ cells, we decided to explore the role of Fas and FasL in self-antigen-induced CD8 downregulation. To this end, we quantified Fas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33841416
DOI: 10.3389/fimmu.2021.635862
PMCID: PMC8024570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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