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Article

Three-dimensional conformation at the H19/Igf2 locus supports a model of enhancer tracking

9 Jul 2008

Abstract excerpt

Insight into how the mammalian genome is structured in vivo is key to understanding transcriptional regulation. This is especially true in complex domains in which genes are coordinately regulated by long-range interactions between cis-regulatory elements. The regulation of the H19/Igf2 imprinted region depends on the presence of several cis-acting sequences, including a methylation-sensitive insulator between...

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PMID: 18617529
DOI: 10.1093/hmg/ddn200

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Three-dimensional conformation at the H19/Igf2 locus supports a model of enhancer trackingPMID 18617529Read ↗

CTCF binding at the <i>H19</i> imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to <i>Igf2</i>Semantic proximity Read ↗

A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele.Semantic proximity Read ↗

The 5' flank of mouse H19 in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication.Semantic proximity Read ↗

Mechanisms of Igf2/H19 Imprinting: DNA Methylation, Chromatin and Long-Distance Gene RegulationSemantic proximity Read ↗

A transcriptional insulator at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Multiple Nucleosome Positioning Sites Regulate the CTCF-Mediated Insulator Function of the H19 Imprinting Control Region†Semantic proximity Read ↗

Analysis of the <i>H19ICR</i> InsulatorSemantic proximity Read ↗

Regulatory mechanisms at the mouse Igf2/H19 locus.Semantic proximity Read ↗

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.Semantic proximity Read ↗

Location of enhancers is essential for the imprinting of H19 and Igf2 genes.Semantic proximity Read ↗

CpG methylation regulates the Igf2/H19 insulator.Semantic proximity Read ↗

Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.Semantic proximity Read ↗

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