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Article

Effect of environmental factors on the dominant lethality caused by expression of a mutated DnaA protein with decreased intrinsic ATPase activity.

FEMS microbiology letters - 1 Feb 1998

Sakamoto K, Makise M, Tsuchiya T, Mizushima T

Abstract excerpt

Induction of a mutant DnaA protein (DnaA E204Q) with decreased intrinsic ATPase activity in cells was previously shown to cause overinitiation of chromosomal DNA replication and a dominant lethal phenotype. Here it is shown that the dominant lethality required incubation at high temperatures; cells harboring the expression plasmid of DnaA E204Q showed very weak colony formation ability (less than 1/10(5) that of...

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Identifiers

PMID: 9485598
DOI: 10.1111/j.1574-6968.1998.tb12846.x

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