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Article

Evidence against linkage of familial combined hyperlipidemia to the apolipoprotein AI-CIII-AIV gene complex.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 1998

Wijsman E M, Brunzell J D, Jarvik G P, Austin M A, Motulsky A G, Deeb S S

Abstract excerpt

Familial combined hyperlipidemia (FCHL) was originally described as a disorder characterized by elevated levels of either plasma cholesterol or triglyceride (TG) or both in members ofthe same family. More recent studies have indicated that apolipoprotein B levels (apoB) are also elevated in these individuals. Although a dominant mode of inheritance was originally proposed, recent studies have questioned this...

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PMID: 9484986
DOI: 10.1161/01.atv.18.2.215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Evidence against linkage of familial combined hyperlipidemia to the apolipoprotein AI-CIII-AIV gene complex.PMID 9484986Read ↗

Genetics of familial combined hyperlipidemia and risk of coronary heart disease.Semantic proximity Read ↗

Replication of linkage of familial combined hyperlipidemia to chromosome 1q with additional heterogeneous effect of apolipoprotein A-I/C-III/A-IV locus. The NHLBI Family Heart Study.Semantic proximity Read ↗

Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels.Semantic proximity Read ↗

Novel genes for familial combined hyperlipidemia.Semantic proximity Read ↗

Association between genetic variation at the APO AI-CIII-AIV gene cluster and familial combined hyperlipidaemia.Semantic proximity Read ↗

Two newly identified SNPs in the APO AI-CIII intergenic region are strongly associated with familial combined hyperlipidaemia.Semantic proximity Read ↗

Two polymorphisms in the apo A-IV gene and familial combined hyperlipidemia.Semantic proximity Read ↗

A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11.Semantic proximity Read ↗

Linkage of a candidate gene locus to familial combined hyperlipidemia: lecithin:cholesterol acyltransferase on 16q.Semantic proximity Read ↗

Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia.Semantic proximity Read ↗

Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia.Semantic proximity Read ↗

Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes.Semantic proximity Read ↗

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