Article
Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia.
Circulation research - 13 Jun 2003
Allayee Hooman, Castellani Lawrence W, Cantor Rita M, de Bruin Tjerk W A, Lusis Aldons J
Abstract excerpt
Apolipoprotein A-II (apoA-II) is a major protein on high-density lipoprotein (HDL) particles, and in mice, its levels are associated with triglyceride and glucose metabolism. In particular, transgenic mice overexpressing apoA-II exhibit hypertriglyceridemia, increased body fat, and insulin resistance, whereas apoA-II-null mice have decreased triglycerides and increased insulin sensitivity. Given the phenotypic...
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