Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes.

doi:10.1172/JCI119260

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Article

Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes.

The Journal of clinical investigation - 1 Mar 1997

Dallinga-Thie G M, van Linde-Sibenius Trip M, Rotter J I, Cantor R M, Bu X, Lusis A J, de Bruin T W

Abstract excerpt

Familial combined hyperlipidemia (FCH) is a common genetic lipid disorder in Western societies. In a recent report (Dallinga-Thie, G.M., X.D. Bu, M. van Linde-Sibenius Trip, J.I. Rotter, A.J. Lusis, and T.W.A. de Bruin. J. Lipid Res., 1996, 36:136-147) we have studied three restriction enzyme pol...

Topics

Adult
Alleles
Apolipoproteins
Apolipoproteins C
Cholesterol
Chromosomes, Human, Pair 11
DNA
Female
Gene Expression Regulation
Genetic Linkage
Haplotypes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hyperlipidemia, Familial Combined

Male

Middle Aged

Multigene Family

Pedigree

Polymorphism, Genetic

Source

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Identifiers

PMID: 9062353
DOI: 10.1172/JCI119260
PMCID: PMC507903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9062353-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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