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Article

Low glutathione pools in the original pso3 mutant of Saccharomyces cerevisiae are responsible for its pleiotropic sensitivity phenotype.

Current genetics - 1 Jan 1998

Brendel M, Grey M, Maris A F, Hietkamp J, Fesus Z, Pich C T, Dafré A L, Schmidt M, Eckardt-Schupp F, Henriques J A

Abstract excerpt

The original pso3-1 mutant isolate of the yeast Saccharomyces cerevisiae exhibits a pleiotropic mutagen-sensitivity phenotype that includes sensitivity to UVA-activated 3-carbethoxypsoralen, to UVC-light, to mono- and bi-functional nitrogen mustard, to paraquat, and to cadmium; on the other hand, it shows hyper-resistance (HYR) to nitrosoguanidine when compared to established wild-type strains. Also, the original...

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PMID: 9472073
DOI: 10.1007/s002940050301

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Low glutathione pools in the original pso3 mutant of Saccharomyces cerevisiae are responsible for its pleiotropic sensitivity phenotype.PMID 9472073Read ↗

Further phenotypic characterization of pso mutants of Saccharomyces cerevisiae with respect to DNA repair and response to oxidative stress.Semantic proximity Read ↗

Mutant pso8-1 of Saccharomyces cerevisiae, sensitive to photoactivated psoralens, UV radiation, and chemical mutagens, contains a rad6 missense mutant allele.Semantic proximity Read ↗

RNR4 mutant alleles pso3-1 and rnr4Delta block induced mutation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Psoralen-sensitive mutant pso9-1 of Saccharomyces cerevisiae contains a mutant allele of the DNA damage checkpoint gene MEC3.Semantic proximity Read ↗

Increased DNA double strand breakage is responsible for sensitivity of the pso3-1 mutant of Saccharomyces cerevisiae to hydrogen peroxide.Semantic proximity Read ↗

The DNA repair gene PSO3 of Saccharomyces cerevisiae belongs to the RAD3 epistasis group.Semantic proximity Read ↗

The pso mutants of Saccharomyces cerevisiae comprise two groups: one deficient in DNA repair and another with altered mutagen metabolism.Semantic proximity Read ↗

Allelism of Saccharomyces cerevisiae genes PSO6, involved in survival after 3-CPs+UVA induced damage, and ERG3, encoding the enzyme sterol C-5 desaturase.Semantic proximity Read ↗

Yeast mutants as a model system for identification of determinants of chemosensitivity.Semantic proximity Read ↗

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Overexpression of the SNQ3/YAP1 gene confers hyper-resistance to nitrosoguanidine in Saccharomyces cerevisiae via a glutathione-independent mechanism.Semantic proximity Read ↗

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