Article
Increased DNA double strand breakage is responsible for sensitivity of the pso3-1 mutant of Saccharomyces cerevisiae to hydrogen peroxide.
Mutation research - 10 May 2001
Brozmanová J, Vlcková V, Farkasová E, Dudás A, Vlasáková D, Chovanec M, Mikulovská Z, Fridrichová I, Saffi J, Henriques J A
Abstract excerpt
Escherichia coli endonuclease III (endo III) is the key repair enzyme essential for removal of oxidized pyrimidines and abasic sites. Although two homologues of endo III, Ntgl and Ntg2, were found in Saccharomyces cerevisiae, they do not significantly contribute to repair of oxidative DNA damage in vivo. This suggests that an additional activity(ies) or a regulatory pathway(s) involved in cellular response to...
Topics
- Bleomycin
- DNA Damage
- Deoxyribonuclease (Pyrimidine Dimer)
- Electrophoresis, Gel, Pulsed-Field
- Endodeoxyribonucleases
- Escherichia coli
- Escherichia coli Proteins
- Genes, Fungal
- Genetic Complementation Test
- Hydrogen Peroxide
- Methyl Methanesulfonate
- Mutagens