Article
The puc1 cyclin regulates the G1 phase of the fission yeast cell cycle in response to cell size.
Molecular biology of the cell - 1 Feb 2000
Martín-Castellanos C, Blanco M A, de Prada J M, Moreno S
Abstract excerpt
Eukaryotic cells coordinate cell size with cell division by regulating the length of the G1 and G2 phases of the cell cycle. In fission yeast, the length of the G1 phase depends on a precise balance between levels of positive (cig1, cig2, puc1, and cdc13 cyclins) and negative (rum1 and ste9-APC) regulators of cdc2. Early in G1, cyclin proteolysis and rum1 inhibition keep the cdc2/cyclin complexes inactive. At the...
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