Article
A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes.
Molecular biology of the cell - 1 Dec 1997
Yamaguchi S, Murakami H, Okayama H
Abstract excerpt
In the fission yeast Schizosaccharomyces pombe, p34(cdc2) plays a central role controlling the cell cycle. We recently isolated a new gene named srw1(+), capable of encoding a WD repeat protein, as a multicopy suppressor of hyperactivated p34(cdc2). Cells lacking srw1(+) are sterile and defective...
Topics
- Amino Acid Sequence
- CDC2 Protein Kinase
- Cell Cycle
- Cell Cycle Proteins
- Cell Differentiation
- Cloning, Molecular
- Cyclin B
- Cyclins
- Fertility
- Fungal Proteins
- Genes, Fungal
- Genes, Lethal
- Genes, Suppressor
- Mitosis
- Models, Biological
- Molecular Sequence Data
- Mutation
- Nitrogen