Article
Role of the alpha-, beta-, and gamma-subunits of epithelial sodium channel in a model of polygenic hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 1997
Kreutz R, Struk B, Rubattu S, Hübner N, Szpirer J, Szpirer C, Ganten D, Lindpaintner K
Abstract excerpt
The pathophysiological basis of Liddle's syndrome, a rare autosomal dominant form of arterial hypertension, has been found to rest on missense mutations or truncations of the beta- and gamma-subunits of the epithelial sodium channel. The hypothesis has been advanced that molecular variants of the...
Topics
- Animals
- Base Sequence
- Chromosome Mapping
- Crosses, Genetic
- DNA
- Epithelial Sodium Channels
- Female
- Gene Expression
- Genetic Linkage
- Genotype
- Hypertension
- In Situ Hybridization, Fluorescence
- Kidney
- Lod Score
- Male
- Molecular Sequence Data
- Mutation
- RNA, Messenger