Article
Haplotype analysis to determine the position of a mutation among closely linked DNA markers.
Human molecular genetics - 1 Jul 1993
Ramsay M, Williamson R, Estivill X, Wainwright B J, Ho M F, Halford S, Kere J, Savilahti E, de la Chapelle A, Schwartz M
Abstract excerpt
Positional cloning involves first finding linkage between an inherited phenotype (such as a disease) and a DNA marker, followed by the use of a variety of physical and genetic mapping techniques to move from linkage to mutation. If there is a founder effect within a population, crossovers are often rare between the mutation causing the phenotype and closely situated markers and increasing disequilibrium may be...
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